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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC6A6 All Species: 10.61
Human Site: Y578 Identified Species: 23.33
UniProt: P31641 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P31641 NP_001127839.1 620 69830 Y578 P F L V R V K Y L L T P R E P
Chimpanzee Pan troglodytes XP_001157641 620 69651 P578 P F L G R L H P T L V P R P P
Rhesus Macaque Macaca mulatta Q9MYX0 630 70239 G582 I I L G Y C I G T S S F V C I
Dog Lupus familis XP_533741 630 70351 K584 T L P E K F R K L T I P S A D
Cat Felis silvestris
Mouse Mus musculus O35316 621 69837 Y578 P L R V R I K Y L I T P R E P
Rat Rattus norvegicus P31643 621 69850 Y578 P L R V R I K Y L I T P R E P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521283 733 81919 S691 S F I E R I K S V A A P K E L
Chicken Gallus gallus NP_001025771 631 71046 A578 S L I E R I K A G G C P Q G S
Frog Xenopus laevis A7Y2X0 790 87434 V744 F I E R L K L V C S P Q P D W
Zebra Danio Brachydanio rerio NP_001032750 625 69879 A578 P L I E R I K A V A A P V R G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VR07 943 103618 R871 D T F W E R I R N T L R P N I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98 42.7 58.4 N.A. 93.2 93.7 N.A. 71.2 79.4 34.8 78.5 N.A. 29.1 N.A. N.A. N.A.
Protein Similarity: 100 98.3 60.9 72 N.A. 97.4 97.7 N.A. 78.5 88.1 51.9 88.1 N.A. 42.2 N.A. N.A. N.A.
P-Site Identity: 100 53.3 6.6 13.3 N.A. 73.3 73.3 N.A. 33.3 20 0 26.6 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 60 13.3 26.6 N.A. 86.6 86.6 N.A. 60 40 6.6 46.6 N.A. 0 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 19 0 19 19 0 0 10 0 % A
% Cys: 0 0 0 0 0 10 0 0 10 0 10 0 0 10 0 % C
% Asp: 10 0 0 0 0 0 0 0 0 0 0 0 0 10 10 % D
% Glu: 0 0 10 37 10 0 0 0 0 0 0 0 0 37 0 % E
% Phe: 10 28 10 0 0 10 0 0 0 0 0 10 0 0 0 % F
% Gly: 0 0 0 19 0 0 0 10 10 10 0 0 0 10 10 % G
% His: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 10 19 28 0 0 46 19 0 0 19 10 0 0 0 19 % I
% Lys: 0 0 0 0 10 10 55 10 0 0 0 0 10 0 0 % K
% Leu: 0 46 28 0 10 10 10 0 37 19 10 0 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 10 0 0 0 0 10 0 % N
% Pro: 46 0 10 0 0 0 0 10 0 0 10 73 19 10 37 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 10 10 0 0 % Q
% Arg: 0 0 19 10 64 10 10 10 0 0 0 10 37 10 0 % R
% Ser: 19 0 0 0 0 0 0 10 0 19 10 0 10 0 10 % S
% Thr: 10 10 0 0 0 0 0 0 19 19 28 0 0 0 0 % T
% Val: 0 0 0 28 0 10 0 10 19 0 10 0 19 0 0 % V
% Trp: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 10 % W
% Tyr: 0 0 0 0 10 0 0 28 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _